Beta Human Papillomavirus and Merkel Cell Polyomavirus in Skin Neoplasms

Combined squamous cell carcinoma and Merkel cell carcinoma of the vulva: Role of human papillomavirus and Merkel cell polyomavirus.

HPV: human papillomavirus MCC: Merkel cell carcinoma MCV: Merkel cell polyomavirus PCR: polymerase chain reaction SCC: squamous cell carcinoma M erkel cell carcinoma (MCC), an uncommon and highly aggressive cutaneous malignancy, usually occurs on the sundamaged skin of the elderly and is characterized by coexpression of neuroendocrine markers and CK20, a discriminant from other types of viscera...

Detection of Merkel cell polyomavirus and human papillomavirus DNA in porocarcinoma.

BACKGROUND Increasing evidences support the role of Merkel cell polyomavirus (MCPyV) and human papillomavirus (HPV) in non-cutaneous and cutaneous tumours. Porocarcinoma is a rare malignant neoplasm that arises from the intraepidermal ductal portion of the eccrine sweat glands. The aetiology of porocarcinoma is largely unknown and no systematic studies have been done to investigate the implicat...

Analysis of human beta papillomavirus and Merkel cell polyomavirus infection in skin lesions and eyebrow hair bulbs from a cohort of chronic lymphocytic leukaemia patients

Merkel Cell Polyomavirus Strains in Patients with Merkel Cell Carcinoma

We investigated whether Merkel cell carcinoma (MCC) patients in France carry Merkel cell polyomavirus (MCPyV) and then identified strain variations. All frozen MCC specimens and 45% of formalin-fixed and paraffin-embedded specimens, but none of the non-MCC neuroendocrine carcinomas specimens, had MCPyV. Strains from France and the United States were similar.

Merkel cell polyomavirus and cutaneous Merkel cell carcinoma

Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine skin cancer of elderly patients. Generally, it originates from Merkel cells of the basal layer of the epidermis characterized by typical neuroendocrine granules (neuron-specific enolase; NSE+) and keratin filament (cytokeratin-20; CK20). Its incidence has been increasing in the last two decades, likely because of improved ability t...